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Symptoms may include painful swallowing (odynophagia) and difficulty swallowing (dysphagia).It is often associated with impaired immune function (e.g.The appearance and distribution of sores is typically presents as multiple, round, superficial oral ulcers, accompanied by acute gingivitis.Adults with atypical presentation are more difficult to diagnose.Even microscopic abrasions on mucous membranes are sufficient to allow viral entry.

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In the presence of a certain gene variation (APOE-epsilon4 allele carriers), HSV-1 appears to be particularly damaging to the nervous system and increases one's risk of developing Alzheimer's disease.Herpes simplex virus 2 is typically contracted through direct skin-to-skin contact with an infected individual, but can also be contracted by exposure to infected saliva, semen, vaginal fluid, or the fluid from herpetic blisters.To infect a new individual, HSV travels through tiny breaks in the skin or mucous membranes in the mouth or genital areas.HIV/AIDS, immunosuppression in solid organ transplants). Neonatal herpes simplex is a HSV infection in an infant.It is a rare but serious condition, usually caused by vertical transmission of HSV-1 or -2) from mother to newborn.

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